GATE IO FLOKI

Purine and pyrimidine nucleoside analogues show promise as antiviral compounds, effective both in tissue culture and in vivo

Purine and pyrimidine nucleoside analogues show promise as antiviral compounds, effective both in tissue culture and in vivo. Those with selective virus inhibition, low toxicity, and efficacy in animals become nucleoside glycoside antiviral drugs. Established drugs include iodine glycosides, trifluorothymidine, and acyclovir. Others, like ribavirin and arabinosyl adenosine monophosphate, are undergoing clinical trials. These analogues, structurally similar to nucleic acid precursors, interfere with nucleic acid synthesis, selectively inhibiting viral nucleic acids while sparing cellular synthesis. Ongoing research aims to develop new antiviral nucleoside compounds.